FORMULASI DAN EVALUASI NANOSUSPENSI SERTA PRODUKSI ULANG NANOEMULSI EKSTRAK ETANOL BUNGA KASUMBA TURATE (CARTHAMUS TINCTORIUS L.)
Formulation of nanoparticles (nanoemulsion, nanosuspension) has been developed lately to improve pharmacological activity of drug. Safflower (Carthamus tinctorius L.) has many pharmacological effects, one of which is as an immunomodulator. The aims of this study were to produce the stable nanosus...
Saved in:
| Main Author: | |
|---|---|
| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/48733 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Formulation of nanoparticles (nanoemulsion, nanosuspension) has been developed lately to improve
pharmacological activity of drug. Safflower (Carthamus tinctorius L.) has many pharmacological effects,
one of which is as an immunomodulator. The aims of this study were to produce the stable
nanosuspension formula and to reproduce nanoemulsion formula that contained kasumba turate’s
ethanol extract. The combination methods of high shear homogenization (speed of 3,600 rpm for 13
minutes) and ultrasonication with 70% amplitude, 45:15 pulse for 5 minutes were applied to make
nanosuspension. The combination methods were also applied to make nanoemulsion, with a speed of
3,600 rpm for 6 minutes on high shear homogenization method and 70% amplitude, 45:15 pulse for 10
minutes on ultrasonication methods. The best nanosuspension formula was obtained using a single
surfactant, namely sodium lauryl sulfate (1%), with 219.9 nm particle size and 0.334 polydispersity
index. Existing nanoemulsion formula can be reproduced. Nanosuspension and nanoemulsion were
physically stabled at temperatures 4, 25 and 40°C for 28 days and 15 days. Nanosuspension in the freeze
and thaw test stabled for 5 cycles.
|
|---|