OPTIMASI PEMBENTUKAN KOKRISTAL KALIUM DIKLOFENAK DENGAN L-PROLIN

• Main Author: Windy Komara, Sheilla
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/48737
• Institution: Institut Teknologi Bandung

Diclofenac is an NSAID class of drugs which has very low water solubility. It was reported that diclofenac acid (AD) and sodium diclofenac (ND) can form cocrystal with proline coformers (PRO) which has higher solubility than AD. Potassium diclofenac (KD) has higher solubility than ND in the water, it is expected that KD-PRO cocrystal solubility has higher value compared to ND-PRO cocrystal. Based on the physical interactions screening, KD and PRO can form new cocrystal phases formed at molar 1: 1. Based on FTIR characterization, the most optimal method and solvent for KDPRO cocrystal formation was Solvent Evaporation (SE) method with ethanol solvent. KDPRO cocrystal made through SE method with ethanol and also with and without humidity control can form two forms of pseudopolymorph, KDPRO monohydrate and tetrahydrate crystals, proved by the reduced weight on the TG profile of 13,825% in cocrystal that formed without humidity control and 4.01 % in cocrystal that formed with humidity control. KDPRO monohydrate and tetrahydrate cocrystal new phases were showed in PXRD characterization through the existence of new peaks at 7.94o , 18.7o , 19.92o , 22.32o , 23.95o , 25.53o , 27.54o , 30.11o , 34.59o , 36.26o and other new peaks in KDPRO tetrahydrate at 3.97o , 11.93o , 15.9o . The dissolution test showed KDPRO cocrystal has a maximum release of up to 100% in the 5th minute compared to KD which has a maximum release of 94.6% in the 15th minute in intestine condition. Stability test showed that KDPRO monohydrate cocrystal was stable on the outdoor for 24 hours, while KDPRO tetrahydrate cocrystal was stable at the temperature of 50o C for 2 days.