FUNCTIONALIZED MULTI-WALLED CARBON NANOTUBES/SILVER NANOPARTICLES COMPOSITE ELECTROCHEMICAL SENSOR FOR DOPAMINE DETECTION
Nowadays, healthcare system in Indonesia still tends to be reactive. To prevent this problem, the development of non-invasive sensor as diagnostic tools to help each individual monitors their own health dynamic with simple and affordable point-ofcare testing system are still ongoing. One way to f...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/49076 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Nowadays, healthcare system in Indonesia still tends to be reactive. To prevent this
problem, the development of non-invasive sensor as diagnostic tools to help each
individual monitors their own health dynamic with simple and affordable point-ofcare testing system are still ongoing.
One way to find out deeper body health information is by producing non-invasive
sensor which can detect analyte in biofluid. Dopamine (DA) is one of the important
analytes that plays a role as neurotransmitter in kidney, cardiovascular system and
central nervous system. Normal DA concentration in biofluid are 0-0.25 nM in
blood and 0.3-3 µM in urine, as in sweat is still on research.
In this final assignment, a research is conducted to f-MWCNT/AgNPs
nanocomposite material which has unique properties and characteristic as
sensitive electrochemical sensor material to detect DA in biofluid. The SEM dan
EDS characterization show the success of functionalization and silver metal nanocompositing process to MWCNT. However, the optimization synthesis steps to
increase the number of AgNPs cannot be done because of the COVID-19 pandemic
condition during the research time.
Based on the Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV)
testing, the value of sensitivity, linearity, linear range, limit of detection (LOD),
limit of quantification (LOQ) and selectivity of f-MWCNT/AgNPs material which is
modified on Glassy Carbon Electrode (GCE) are obtained. From this research, the
obtained LOD values are 0.2778 µM on anodic peak and 0.2263 µM on cathodic
peak which are lower than the minimal normal DA concentration value in human
urine. These results show that the synthesized f-MWCNT/AgNPs sensor material
can detect DA analyte in human urine biofluid.
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