SYNTHESIS OF POLYVINYL ALCOHOL (PVA)/CASSAVA LEAVES EXTRACT (CLE) HYDROGEL WITH PHYSICAL AND ANTIBACTERIAL CHARACTERISTICS
The hydrogel has a porous structure that allows a large water absorption rate, non-adhesive, flexible, hydrophilic, and biocompatible. Hydrogel has been used as a wound dressing because it can accelerate the healing process of chronic wounds. The mechanical strength provides excellent biomaterial re...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/49582 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The hydrogel has a porous structure that allows a large water absorption rate, non-adhesive, flexible, hydrophilic, and biocompatible. Hydrogel has been used as a wound dressing because it can accelerate the healing process of chronic wounds. The mechanical strength provides excellent biomaterial resistance by reducing the rate of degradation. In this study, the polyvinyl alcohol (PVA) polymer hydrogel synthesized through physical crosslinking with cassava leaf extract (CLE) as the active compound. Cassava leaves have active substances in the form of flavonoids, which act as antibacterials. The resulting viscosity of the solution decreases with increasing mass of CLE due to the decrease in the average length of the polymer chain. The pH measurement results of the PVA solution were in normal conditions, it was 6,910, and the pH of the solution decreased with CLE. The pH value is less than six so that it can inhibit bacterial growth. SEM characterization results showed that PVA/CLE hydrogel surface was not smooth with a porous structure.
The FTIR indicates the presence of phenol groups in the range of wavenumbers 3336 cm-1. XRD results showed the change in crystallinity in PVA to amorphous for PVA hydrogels and PVA/CLE hydrogels due to the interaction between CLE, H2O, and PVA chains.
In general, the hydrogel with more CLE mass has a larger porous structure that allows for more water absorption. Hydrogel with a porous structure has a large absorption capacity so that it can absorb wound exudates. It is useful in the hemostatic process in wound healing. The calorific melt value and the degree of hydrogel crystallinity decreased with CLE. The increase in water absorption capacity decreases the compressive modulus and compressive strength. The number of bacterial colonies on the hydrogel decreased with the addition of CLE mass, and the antibacterial activity increased. The highest antibacterial activity value was 25,292 %/g. |
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