KAJIAN PUSTAKA METODE PENINGKATAN KELARUTAN DAN BIOAVAILABILITAS HALOPERIDOL

• Main Author: Silmi Kaffah, Vivi
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/50022
• Institution: Institut Teknologi Bandung

Solubility is a compilation to mix with other compositions that form a homogeneous phase. In the pharmaceutical field, solubility is important in determining dosage forms and being one of the determinants of the number of drugs that reach the systemic circulation. This literature review aims to examine and compare haloperidol delivery methods that complement the increased solubility and bioavailability. At the end of this end, delivery of haloperidol leads to the intranasal route by using nanoparticle-carrying carrier particles such as lipid nanoparticles (SLN), poly (ethylene glycol) -block-poly (D, L) -lactic-co-glycolic acid (PEG - lipid) PLGA), and dendrimers. However, oral delivery, injection, and transdermal???®í ?? ??® ????±???ð?ã ?ð?, ±??±®?ð® »??? ?ð??, »??? ?ð???» ?- cyclodextrin complexes, succinoglycan oligosaccharide dimer complexes, and proniosomes, and raised salts. Salt forming is a method that has been used in haloperidol preparations available on the market. Judging from the safety, quality, and ability of targeting haloperidol, intranasal preparations with dendrimer formulas have the best characteristics.