STUDI LITERATUR METABOLIT SEKUNDER JAMUR YANG BERASAL DARI LAUT DENGAN AKTIVITAS SITOTOKSIK TERHADAP SEL KANKER PANKREAS

• Main Author: Lestari, Indri
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/50480
• Institution: Institut Teknologi Bandung

The search for source of new medicinal compounds with anticancer activity from natural products become important to resolve ineffectiveness problems of pancreatic cancer therapy due to pancreatic cancer cell resistance. Marine-derived fungi secondary metabolites are known to possess unique chemical structure and quite broad biological activity, including anticancer activity. This study was conducted to collect and research the data of marine fungi secondary metabolites with anticancer activity against pancreatic cancer cell. The performed study method was literature review with systematic approach. Eight journals were collected as a result from literature search using search engine on PubMed (https://pubmed.ncbi.nlm.nih.gov/) and Google Scholar (https://scholar.google.com/) database and literature screening based on inclusion criteria, subsequently made as information containing data of marine fungi secondary metabolite with cytotoxic activity against pancreatic cancer cell, marine fungi secondary metabolite isolation, and cytotoxic activity screening. Since 2010 until now, there were 20 secondary metabolites compounds from marine fungi with cytotoxic activity against pancreatic cancer cell, namely one benzophenone derivatives, one epidithiodiketopiperazine derivative, two butenolide derivatives, two cladosporol derivatives, four bisthiodiketopiperazine derivatives, five tetranorditerpenoid derivatives, three azaphilone derivatives, and one ?-pyrone derivative. Result of cytotoxic activity screening such as MTT assay, WST-8 assay, or trypan blue exclusion assay showed that most of the secondary metabolites categorized as highly cytotoxic. It indicated that marine-derived fungi secondary metabolites have promising potential as cytotoxic compound especially against pancreatic cancer cell.