STUDI LITERATUR METABOLIT SEKUNDER DARI JAMUR BERASAL DARI LAUT DAN UJI AKTIVITASNYA TERHADAP MYCOBACTERIUM SP.

• Main Author: Merliani, Novi
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/50527
• Institution: Institut Teknologi Bandung

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, which has become one of the global health problems including in Indonesia. Death rates in people affected by this infection can be suppressed by the first-line anti-tuberculosis drugs (ATD) currently in use, but the emergence of multi-drug resistance to M. tuberculosis (MDR-TB) strains is a global concern and the challenge of obtaining a drug new in the treatment of infections that are more effective. Drugs made from natural ingredients, especially from the sea, are alternatives for TB treatment. In recent years marine-derived fungal are of particular concern, because of their ability to produce a number of good and interesting new bioactive compounds that are important in the pharmaceutical field. The aim of this literature study is to collect and examine bioactive compound data from the sea and its potential activity as an anti- TB agent. The obtained 19 journals which were published from 2013 to April 2020 from literature search results using the Google Scholar (https://scholar.google.com/) and Pubmed (https://pubmed.ncbi.nlm.nih.gov/) search egine. There are 45 compounds that have been reported to consist of alkaloid, quinone, xhantone, triterpenoid, polypropionate, pyrone, citrinin, benzophenone, lactone, etc. groups produced by marine fungi (Aspergillus sp., Penicillium sp., Nigrospora sp., Alternaria sp., Arthrinium sp., Zopfiella sp., Gliomastix sp., and Metarhizium sp. with activity as antimycobacteria). The review is consisted by the process of fungal isolation, cultivation, extraction of compounds, separation of compounds, and activity test methods with M. tuberculosis protein tyrosine phosphatase B (MptpB) inhibition test and microdilution test. Potential compounds as anti-TB are classified based on MIC and IC50 values, which are 29 strong, 10 moderate and 5 weak.