EFEK KURKUMIN TERHADAP EKPRESI PUTUS OBAT PADA MODEL MENCIT YANG MENGALAMI KETERGANTUNGAN MORFIN

• Main Author: Octavia Dwiyanti, Siti
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/50772
• Institution: Institut Teknologi Bandung

Cessation of repeated consumption of addictive substance, including the analgesic morphine, can induce expression of withdrawal. Previous results have shown the effect of curcumin on alcohol withdrawal expression. This research aimed to investigate the effect of curcumin on the expression of withdrawal signs in morphine-dependent mice and the accompanying changes in brain BDNF level. Expression of withdrawal was induced by administration of 4 mg/kg naloxone after the mice received escalated dose (10 mg/kg to 80 mg/kg) of morphine in 5 days. Behavioral expression was recorded for 30 minutes during a total of 60 minutes observation. BDNF level was measured after behavioral observation using ELISA. To study its effect, curcumin was administered at 3.2 mg/kg or 10 mg/kg orally 30 minutes before morphine. Results showed that curcumin at 10 mg/kg significantly suppressed the expression of jumping, paw tremor, paw licking, facial preening, grooming, grooming time, rearing, and body weight decrease (p<0.05). Meanwhile, administration of curcumin at 3.2 mg/kg significantly decreased the incidence of paw tremor, paw licking, grooming time, rearing and diarrhea (p<0.05). BDNF was observed at highest level in mice receiving 10 mg/kg curcumin and lowest in control mice. Overall, results of the present research indicated the potential of curcumin to overcome morphine withdrawal.