KAJIAN PUSTAKA METABOLIT SEKUNDER BAKTERI YANG BERASAL DARI LAUT SERTA UJI AKTIVITASNYA TERHADAP JAMUR PATOGEN

• Main Author: Widya Hespatika, Rosya
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/50840
• Institution: Institut Teknologi Bandung

Cases of fungal infections have become a global health problem related to the high morbidity and mortality rates. Phytopathogenic fungal infections are also a problem of the world economy because they cause massive losses in the agriculture industry. Currently, the groups of antifungal drugs are limited to azoles, polyenes, echinocandins, pyrimidine analogs, and allylamines. While it was found that there are various species of pathogenic fungi that have been resistant to these antifungal groups, so, it is now indispensable to find a new antifungal agent with the potential to have a more specific mechanism of action and targets. Marine ecosystems have long been known to produce secondary metabolites with structurally diverse and biologically active compounds. One of the marine ecosystem's biotic components that play the most role in producing secondary metabolites is marine microorganisms such as bacteria. This literature study provides data on bioactive compounds from marine-derived bacteria and the potential antifungal activity of these compounds against pathogenic fungi as well as their activity test methods recorded from 2010 to June 2020. It was found that at least 41 bioactive compounds as potential antifungal agents with details of 16 compounds have structural similarity to polyene antifungal group, two compounds similar to pyrimidine analog group, ten compounds similar to echinocandin group, and 13 compounds did not have structural similarity to the existing antifungal group. These compounds are produced from bacterial species such as Bacillus licheniformis, Bacillus subtilis, Bacillus cereus, Streptomyces puniceus, Actinoalloteichus sp, Pseudomonas putida, and Janthinobacterium sp. The review consisted of the bacterial isolation, cultivation, extraction of compounds, isolation of compounds process, and methods for antifungal activity assay. Potential antifungal compounds based on the results of the MIC values and ????????50 are thirty-nine strong, one moderate, and one weak.