KAJIAN PUSTAKA POLA PERSEBARAN MIKROBA PATOGEN PENYEBAB DIABETIC FOOT INFECTION DAN POLA RESISTENSINYA TERHADAP ANTIBIOTIK

• Main Author: Septiani Radiva, Amalia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/51508
• Institution: Institut Teknologi Bandung

Diabetic Foot Infection (DFI) is one of the complications that major occurs in DM patients as well as being the main factor of lower extremity amputations. Provision of antibiotic therapy in a rational manner and in accordance with the pattern of the pathogenic bacteria that cause DFI is needed to increase the chances of recovery and patient’s quality of life, and also minimize the phenomenon of microbial resistance which is often inversely proportional to the effectiveness of therapy. This research is a literature review that used PubMed and ScienceDirect as the search engines. By finding and researching pathogenic microbial pattern of DFI and its resistance pattern to the antibiotics from 21 articles covering the regions of Africa, South America, North America, South Asia, East Asia, Southeast Asia, Middle East, and Asia-Europe as well, that listed the patterns of pathogenic bacteria of DFI and its correlation with microbial resistance pattern to the antibiotics used. The results obtained were Staphylococcus aureus (19,25%) as predominant aerobic Gram-positive pathogen. Escherichia coli (12,46%) and Pseudomonas aeruginosa (17,73%) were the most common aerobic Gram-negative DFI’s pathogenic bacteria. The pattern of the resistance was mostly found against penicillin group and cephalosporin fourth generation in South Asia, Southeast Asia, and Middle East. The principle of the management of DFI that is written by IWGDF is still relevant to be used as reference, but still, must be referring to local microbial pattern and its resistance pattern against antibiotics in many regions.