KAJIAN PUSTAKA METABOLIT SEKUNDER DAN AKTIVITAS ANTIMIKROBA SERTA EFEK SITOTOKSIK JAMUR TRICHODERMA SP. ASAL LAUT

• Main Author: Selenia, Vega
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/51584
• Institution: Institut Teknologi Bandung

Marine-derived Trichoderma has shown great potential as a promising source of new drug development. Secondary metabolites form this genus has been proven effective against numbers ?» ­ ®?±?ð ????»??ãð???? ?¸ ?í??±¸ ®??????ð®ð?? ã ð???® ?®±?®±???ð?±??????????¸??±?ð ’?? ??? ?±? ?± ? and its biodiversity has not been fully explored and still holds big opportunities to produce beneficial marine resources. The aim of this study was to summarize secondary metabolites of marine-derived Trichoderma sp. and its antimicrobial and cytotoxicity activity. This study was conducted by reviewing articles related to marine-derived Trichoderma and its secondary metabolites in the past ten years. This study included 17 compounds which structures had been elucidated. Compounds 1–3 were tested for its activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv. Compound 4 was evaluated for action against Candida albicans SC5314 and for synergistic antifungal activity. Compounds 5–7 were assayed for its activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 8 and 9 were evaluated for its activity against Staphylococcus aureus, vancomycin-resistant Enterococci (VRE), Bacillus subtilis, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Compound 10–16 displayed cytotoxicity against cancer cell lines. Compound 17 exerted antibacterial activity against Escherichia coli.