FORMULASI DAN EVALUASI SEDIAAN SAMPO DARI EKSTRAK ETANOL RIMPANG TEMULAWAK (CURCUMA XANTHORRHIZA ROXB.) SERTA UJI AKTIVITAS ANTIKETOMBE TERHADAP MALASSEZIA FURFUR
Malassezia furfur is an opportunistic fungus that belongs to skin microflora, this fungus is often found in dandruff hair. One of the active compounds that has been known to have activity to inhibit the growth of Malassezia sp. is xanthorrhizol, which is an identity compound in java turmeric rhizo...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/51753 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Malassezia furfur is an opportunistic fungus that belongs to skin microflora, this fungus is often found
in dandruff hair. One of the active compounds that has been known to have activity to inhibit the
growth of Malassezia sp. is xanthorrhizol, which is an identity compound in java turmeric rhizome
(Curcuma xanthorrhiza Roxb.). This study aims to develop the antidandruff shampoo formulation of
java turmeric extract. The research scope consists of literature review related to liquid shampoo in
general, determination of the antifungal activity of extract, general evaluation of shampoos,
determination of anti-dandruff shampoo activity, the potential toxicity from the materials used, as
well as the potential for discoloration of extract. The following steps of the experiments have been
carried out, including the simplicia characterization, preparation and phytochemical screening of the
extract, process optimization and shampoo base formula optimization qualitatively, and color
simulation test of the extract in the sampo qualitatively. From the simplicia characterization, there are
starch grain, cortical parenchyma, vascular tissue, sclerenchyma fiber, and cork tissue on microscope
testing, water content 5,00±0,00%, water-soluble extractive 15,44±0,54%, ethanol-soluble extractive
21,28±0,42%, total ash content 5,63±0,15%, and lost on drying 2,86±2,83%. In the ethanol extract of
java turmeric rhizome, flavonoid, quinone, and triterpenoid were detected. The base liquid cream
shampoo formula which has the best homogeneity and viscosity consists of 20% SLES, 3% CAPB, 3%
NaCl, 2% glycol distearate, and 2% dimethicone, but the resulting foam is not satisfactory. From the
process optimization with ultraturrax, the optimum results are obtained at a speed of 8000 rpm for 10
minutes. No data were found on the results of research on the antifungal activity of java turmeric
rhizome extract against Malassezia furfur, only data on the antifungal activity of the isolate was found
with MIC 1,25 µg/mL dan MFC 5 µg/mL. The shampoo ingredients used in the study have low potential
for eye and skin irritation.
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