SYNTHESIS OF GLISEROL MONOOLEAT (GMO) WITH ACID CATALYST & MODULE PREPARATION FOR LABORATORY WORK
Glycerol monooleate (GMO) plays an important roles in the field of pharmacy, drugs, oleochemistry, mining, and food’s emulsifier. In this study, glycerol monooleate (GMO) have been succesfully synthesized via multisteps reactions. First, solketal was prepared by protecting two hydroxy groups of glyc...
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| Format: | Theses |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/53607 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Glycerol monooleate (GMO) plays an important roles in the field of pharmacy, drugs, oleochemistry, mining, and food’s emulsifier. In this study, glycerol monooleate (GMO) have been succesfully synthesized via multisteps reactions. First, solketal was prepared by protecting two hydroxy groups of glycerol. This reaction was achieved at 58?C by applying several acid catalysts namely, champor sulfonic acid (CSA), p-toluene sulfonic acid (p-TSA) dan amberlyst-16 with the yield of 9.37%; 12.23% and 51.02% respectively. Amberlyst-16 provided the highest yield among the others and was used for scaling up. Esterification was achieved by using base catalyst Na2CO3 at 100?C and 6 hours. Further purification were done by extraction to remove oleic acid and Na2CO3, while vacuum distillation (kugelroohr) was used to removed solketal. Isopropilidine glycerol oleate (IPGO) had been purified and the yield obtained was 51.81%. The last step of GMO synthesis was deprotection of IPGO. Deprotection reaction was conducted in ethanol 95% as solvent at 56?C for 3 hours, the catalyst used was amberlyst-16, and the product (glycerol monooleate) was obtained with the yield of 73.35%. Characterization and analysis were performed by thin layer chromatography (TLC), 1D and 2D NMR spectroscopy.
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