EFIKASI TERAPI MODAFINIL, SXB DAN KOMBINASINYA UNTUK PENANGANAN EXCESSIVE DAYTIME SLEEPINESS DAN DISRUPTED NIGHTTIME SLEEP PADA PASIEN NARKOLEPSI: SYSTEMATIC REVIEW DAN ANALISIS EFEKTIVITAS-BIAYA
Narcolepsy is a neurological disease resulting in inability of the patients to properly perform daily activities. Treatments of narcolepsy which are focusing on symptomatic management make the therapy of narcolepsy has to be continuously done that can lead to financial burden for the patients. Thi...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/54483 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Narcolepsy is a neurological disease resulting in inability of the patients to properly perform daily
activities. Treatments of narcolepsy which are focusing on symptomatic management make the therapy
of narcolepsy has to be continuously done that can lead to financial burden for the patients. This
systematic review aims to summarize and analyze the efficacy of the recommended first-line therapy
namely modafinil and sodium oxybate (SXB) as well as their combination and to perform costeffectiveness analysis of the therapy. The systematic review was done by searching related articles on
Elsevier Science Direct database through ITB proxy network, using keyword “Modafinil” AND “SXB” AND
“Narcolepsy”. The data were then analyzed descriptively. The results showed that SXB as monotherapy
can be used to manage EDS and DNS in type 1 and type 2 narcolepsy. The use of combination of SXB
and modafinil showed additive effect during trial. It was found that combination of SXB and modafinil
is cost-effective compared to SXB or modafinil as monotherapy.
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