EFEK VIRGIN COCONUT OIL (VCO) TERHADAP GEJALA PUTUS OBAT PASIEN KETERGANTUNGAN HEROIN DI KLINIK PROGRAM TERAPI RUMATAN METADON RUMAH SAKIT HASAN SADIKIN BANDUNG

• Main Author: Juliansyah, Permana
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/54900
• Institution: Institut Teknologi Bandung

Heroin is a substance that can cause the most severe physical and the withdrawal symptoms are stronger. The symptoms are one of the barriers of heroin abusers experiencing to therapy. Last study showed a neuroinflammatory mechanism involvement in drug withdrawal syndrome. Arachidonic acid cascade, which is an essential component of the inflammatory response, has been shown as one of the contributors to the rewarding properties that gives positive feelingwhich should be approached, one of the properties of many addictive substances that stimulates the dependence. Effect of free fatty acid component on the expression of inflammatory inhibition can be used to develop research on Virgin Coconut Oil (VCO) that has a high free fatty acids, especially lauric acid, as an alternative or additional therapy in the treatment of drug dependence. This study was aimed to identify the potential of VCO for treatment of withdrawal syndrome in patients who are undergoing methadone maintenance therapy. Parameters of withdrawal syndrome was determined by pre- and post-study of Subjective Opiate Withdrawal Scale (SOWS) and Objective Opiate Withdrawal Scale (OOWS). Twenty two patients were grouped into 11 patients as a test group who took 50 mL of VCO before administration of methadone and 11 other patients had only methadone dose as a control group. Both parameters were determined one day before the first day (pre-study) and one day after the fourteenth day of therapy (post-study). VCO showed a tendency to reduce withdrawal syndrome, demonstrated by the decrease in Total Point of SOWS (1.45) and OOWS (0.45) in group receiving it. The control group experienced a decline in Total Point SOWS (0.55) and no change in Total Point of OOWS. Total Point of SOWS and OOWS were not significantly different between test and control group (p>0.05). The symptoms of the feeling of wanting to use illicit substances in SOWS and piloerection, tremor, and sweating in OOWS were the most significantly reduced. VCO also demonstrated a tendency to improve the psychological distress that can support the improvement of the quality of life of patients with methadone maintenance therapy. This was indicated by a decrease in the Psychological Distress Kessler-10 Scale (2.75), especially of with respect to anxiety and fatigue. Altogether, results of the present study show that VCO has a tendency to reduce the withdrawal syndorme of heroin-dependent patients, shown by a decrease in Total Point of SOWS, especially the feeling of wanting to use illicit substances; and decrease in Total Point of OOWS, especially piloerection, tremor, and sweating.