PENINGKATAN LAJU DISOLUSI IBUPROFEN MELALUI PEMBENTUKAN DISPERSI PADAT MENGGUNAKAN VARIASI BOBOT MOLEKUL KITOSAN
Ibuprofen is a Non-Steroidal Anti-Inflammatory Drugs that practically insoluble in water but has high permeability. Therefore performance of ibuprofen in a tablet is determined by the rate of dissolution. This research aims to improve disolution rate of ibuprofen using solid dispersion method in...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/55238 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Ibuprofen is a Non-Steroidal Anti-Inflammatory Drugs that practically insoluble in water but has
high permeability. Therefore performance of ibuprofen in a tablet is determined by the rate of
dissolution. This research aims to improve disolution rate of ibuprofen using solid dispersion
method in chitosan with several molecul weight variations. Solid dispersion was made by
solvent evaporation method at various rasio of ibuprofen-chitosan. Electrostatic binding of
ibuprofen-chitosan were optimized including volume ratio of chitosan solution in acid and
ibuprofen solution in ethanol. Physical mixture of ibuprofen-high molecul weight (HM) and
ibuprofen-low molecul weight (LM) used as comparision to formulated solid dispersion.
Solubility dan disolution profile of obtained solid dispersion in HCL 0,1 N pH 1,2, water, and
fosfat buffer pH 7,2 was evaluated. Ibuprofen-HM with rasio 1:1,5 showed the highest solubility
dan disolution rate in HCL 0,1 N pH 1,2. (p<0,05), in contrast ibuprofen-LM with rasio 1:1,5
showed the highest solubility dan disolution rate in water dan fosfat buffer pH 7,2 (p<0,05). FT-
IR spectrum and SEM photograph indicated interaction between ibuprofen and chitosan within
obtained solid dispersion.
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