KAJIAN PUSTAKA KOKRISTAL GARAM OBAT DAN PENGAMATAN INTERAKSI NATRIUM MEFENAMAT-ISONIKOTINAMID
Salt-cocrystal is a solid multi-component system formed from salt and its appropriate neutral coformer. The identification of salt-cocrystal is convoluted, hence a reliable method is necessary. This final paper consists of the literature study portion which aims to examine the identification meth...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/56475 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Salt-cocrystal is a solid multi-component system formed from salt and its appropriate neutral
coformer. The identification of salt-cocrystal is convoluted, hence a reliable method is necessary.
This final paper consists of the literature study portion which aims to examine the identification
method of salt-cocrystal and the experiment portion which aims to determine whether sodium
mefenamate also forms a eutectic mixture with isonicotinamide. According to the literature study,
identification of salt-cocrystal is done by proton transfer degree calculation. The instruments
capable of correctly identifying this form are Single Crystal X-Ray Diffraction (SCXRD) and Solid-state
Nuclear Magnetic Resonance (ssNMR). Mefenamic acid is a nonsteroidal anti-inflammatory agent
(NSAID) drug with very low solubility in water, and sodium mefenamate is the sodium salt form
with higher solubility in water. Both mefenamic acid and sodium mefenamate form cocrystal with
nicotinamide. It has also been reported that mefenamic acid forms a eutectic mixture with
isonicotinamide. According to the electrothermal, DSC, FTIR, and PXRD analysis, the interaction of
sodium mefenamate-isonicotinamide (1:1) system is a simple eutectic, marked by the melting point
which is lower than its constituents, at 66,39°C. The FTIR analysis showed that its spectra are the
overlap of the constituents. The PXRD analysis resulted in the diffractograms of the eutectic mixture
which in harmony showed that it was the combination of the constituents with no novel peak.
Therefore, the sodium mefenamate-isonicotinamide mixture forms a simple eutectic system
without forming a novel multi-component system. Future researches may be developed to
determine the effect of eutectic interaction on the solubility of sodium mefenamate.
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