ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT

Piperine is the secondary metabolite from the piperidine alkaloid group in black pepper (Piper nigrum L.) with extremely low solubility in water. Multicomponent crystals formation is one way of improving the solubility and dissolution rate of piperine. In this research, we will form the multicomp...

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Main Author: Farah Fauziah, Alya
Format: Final Project
Language:Indonesia
Online Access:https://digilib.itb.ac.id/gdl/view/56483
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:56483
spelling id-itb.:564832021-06-22T14:33:23ZANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT Farah Fauziah, Alya Indonesia Final Project piperine, multicomponent crystal, oxalic acid dihydrate, azelaic acid, maleic acid INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/56483 Piperine is the secondary metabolite from the piperidine alkaloid group in black pepper (Piper nigrum L.) with extremely low solubility in water. Multicomponent crystals formation is one way of improving the solubility and dissolution rate of piperine. In this research, we will form the multicomponent crystals of piperine (PIP) with dihydrate oxalic acid (OKS), azelaic acid (AZE), and maleic acid (MAL) in molar ratio each of 1:1, the preferred method is solvent evaporation with methanol. The multicomponent crystal formation begins with creating the binary phase diagram to observe the probability of solid interactions as well as determining the appropriate molar ratio. The obtained crystals were then characterized by electrothermal, DSC, FTIR, and PXRD instruments. The melting points of PIP-OKS, PIP-AZE, and PIP-MAL are 65,6-125 °C, 76-123,9 °C, and 60,8-129,5 °C, respectively. The FTIR spectrum of PIP-OKS, PIP-AZE, and PIP-MAL showed a similar pattern and on each spectrum, novel peaks were observed at wavenumber 3467 cm -1 . The diffractograms of PIP- OKS, PIP-AZE, and PIP-MAL were different from it physical mixture, however, the three crystals showed similar diffraction peaks, which were at 2?= 4,8°, 13,4°, 19,2°, 21,5°, 23,4°, 27,2°, and 29,2°. The DSC analysis for the PIP-OKS crystal and PIP-AZE crystal showed endothermic peak at 94 °C and 99,6 °C. From this research, it can be inferred that a novel crystal phase has formed due to the interaction of piperine with dihydrate oxalic acid, azelaic acid, and maleic acid, which exhibited similar crystal structure or known as isomorph. text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
description Piperine is the secondary metabolite from the piperidine alkaloid group in black pepper (Piper nigrum L.) with extremely low solubility in water. Multicomponent crystals formation is one way of improving the solubility and dissolution rate of piperine. In this research, we will form the multicomponent crystals of piperine (PIP) with dihydrate oxalic acid (OKS), azelaic acid (AZE), and maleic acid (MAL) in molar ratio each of 1:1, the preferred method is solvent evaporation with methanol. The multicomponent crystal formation begins with creating the binary phase diagram to observe the probability of solid interactions as well as determining the appropriate molar ratio. The obtained crystals were then characterized by electrothermal, DSC, FTIR, and PXRD instruments. The melting points of PIP-OKS, PIP-AZE, and PIP-MAL are 65,6-125 °C, 76-123,9 °C, and 60,8-129,5 °C, respectively. The FTIR spectrum of PIP-OKS, PIP-AZE, and PIP-MAL showed a similar pattern and on each spectrum, novel peaks were observed at wavenumber 3467 cm -1 . The diffractograms of PIP- OKS, PIP-AZE, and PIP-MAL were different from it physical mixture, however, the three crystals showed similar diffraction peaks, which were at 2?= 4,8°, 13,4°, 19,2°, 21,5°, 23,4°, 27,2°, and 29,2°. The DSC analysis for the PIP-OKS crystal and PIP-AZE crystal showed endothermic peak at 94 °C and 99,6 °C. From this research, it can be inferred that a novel crystal phase has formed due to the interaction of piperine with dihydrate oxalic acid, azelaic acid, and maleic acid, which exhibited similar crystal structure or known as isomorph.
format Final Project
author Farah Fauziah, Alya
spellingShingle Farah Fauziah, Alya
ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT
author_facet Farah Fauziah, Alya
author_sort Farah Fauziah, Alya
title ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT
title_short ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT
title_full ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT
title_fullStr ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT
title_full_unstemmed ANALISIS INTERAKSI PADATAN PIPERIN DENGAN BEBERAPA ASAM DIKARBOKSILAT
title_sort analisis interaksi padatan piperin dengan beberapa asam dikarboksilat
url https://digilib.itb.ac.id/gdl/view/56483
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