EVALUATION OF PROPHYLAXIS ANTIBIOTIC IN SURGICAL PATIENTS AND ITS EFFECT ON SURGICAL SITE INFECTION AT HASAN SADIKIN HOSPITAL, BANDUNG

• Main Author: Hanifah Az-Zahra Anwar, Sarah
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56535
• Institution: Institut Teknologi Bandung

Presents Prophylaxis antibiotic on surgery are intended to prevent wound infection in the surgical area. Inappropriate of prophylaxis antibiotic carries the risk of causing (Surgical Site Infection) SSI events. Antibiotic resistance cannot be eliminated, but its development can be inhibited by using rational antibiotic. Analysis of drug-related problems (DRPs) in the use of prophylactic antibiotic can be evaluated qualitatively using the Gyssens method and quantitatively using the (ATC/DDD) method to determine the value of DDD and Drug Utilization (DU) 90% of antibiotic used in surgical patients. The aim of the study was to evaluate the use of prophylactic antibiotic used and to analyze the causative factors of SSI in patients who were given preoperative antibiotic. The study was conducted retrospectively by taking medical record data samples from patients who underwent surgery, were hospitalized in the Kana and Kemuning ward in 2019. The results showed that 75.65% of medical record data with the right use of antibiotic. There was an inappropiate of the timing of administration in 22.17% of cases and no indication of antibiotic in 1.18% of cases. Based on the results of DDD calculations, cefazolin is the most widely administered prophylactic antibiotic, and included in the Drug Utilization (DU) 90% segment, which means that 90% of the use of prophylactic antibiotic is cefazolin. From the 424 samples taken, 8 of them had SSI. Analysis was conducted to observe the relationship between the timing and dose of prophylaxis antibiotic with the incidence of SSI. The results of the Fisher Exact analysis showed that at the dose of administration (p ?0.05) there was no relationship between cefazolin dose and the incidence of SSI, meaning that the administration of 1 g or 2 g had no effect on the incidence of SSI. The timing of prophylaxis antibiotic with p = 0.002 indicates that, statistically, there is a significant relationship between the timing of prophylaxis antibiotic and the incidence of the SSI, meaning that the timing of prophylaxis antibiotic has an effect on the incidence of SSI.