STUDI LITERATUR TUMBUHAN INDONESIA YANG BERPOTENSI SEBAGAI KEMOPREVENTIF KANKER KOLOREKTAL
Nowadays, colorectal cancer is still a world health problem. Colorectal cancer is cancer that occurs in the colon or rectum. In Indonesia, colorectal is the forth, but most commonly occurs in both gender than in other cancers. Currently, chemotherapy is a treatment used to kill cancer cells, but i...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/56553 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Nowadays, colorectal cancer is still a world health problem. Colorectal cancer is cancer that occurs in
the colon or rectum. In Indonesia, colorectal is the forth, but most commonly occurs in both gender
than in other cancers. Currently, chemotherapy is a treatment used to kill cancer cells, but its use had
dangerous side effects. Indonesian plants already exist that are used to treat cancer and have the
potential to be an alternative to chemotherapy. This literature study aims to collect data on Indonesian
plants that have the potential as chemoprevention of colorectal cancer. Literature searches are carried
out through search engines on the Pubmed and Google Scholar with keywords and through hand
searching with literatures selected through certain inclusion and exclusion criteria. The results obtained
103 literature grouped based on in vitro tests, in vivo tests, and clinical trials for analyzed. Based on the
results of research, literature studies obtained 73 plants from 46 tribes had potential as
chemoprevention of colorectal cancer. The potential for cytotoxic activity of plants based on IC50 values,
namely, 5 strong; 35 moderate; 9 weak; 6 not cytotoxic; and 20 could not be determined, but it was
not representative because other parameters were not included. 7 plants tested in vitro and in vivo
have a proportional effect. The mechanism of each plant varies both cellular and molecular. Only 4
plants are still conducting in clinical trials phases, namely Allium sativum L., Annona muricata L.,
Camellia sinensis (L.) Kuntze, and Zingiber officinale Roscoe showed that can prevented or suppressed
the growth of colorectal cancer. Based on the safety evaluation, the administration of these plant is
safe for consumption and can be tolerated, but there are still side effects in a small proportion of
patients.
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