STUDI LITERATUR TUMBUHAN POTENSIAL DALAM PENANGANAN RESISTENSI BAKTERI TERHADAP ANTIBIOTIK

• Main Author: Miralda Sembiring, Natalia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56561
• Institution: Institut Teknologi Bandung

Antibiotic resistance nowadays become issue while bacterial cannot be killed by current medications because of its defensive mechanism that causing resistance. There are five types of bacterial resistances noticeably such as Methicillin-resistant Staphylococcus aureus (MRSA), Carbapenem Resistant Enterobacteriaceae (CRE), Vancomycin Resistant Enterococcus (VRE), Extended Spectrum Beta-Lactamase (ESBL), and Multi-drug Resistant TB (MDR-TB). Infections by resistant bacteria often causing worsening pathophysiology. Research on synthetic antibiotics has taken an excessively long time, so that the use of plants exist as an option to treat bacterial resistance. Literature study done by analysing potential family plants to resist bacterial resistance based on plants’species that were collected previously. Review done from Google Scholar and Pubmed NCBI. The results were classified into in vitro and in vivo tests toward MRSA, VRE, MDR-TB, ESBL, and CRE. There are four plant families tested most and active based on in vitro tests. Euphorbiaceae found mostly tested and active on MRSA and VRE through Euphorbia hirta, Jatropha multifida, Ricinus communis, and Phyllanthus niruri. Zingiberaceae, through Curcuma caesia, Curcuma longa L., and Kaempferia galanga actively tested for MDR-TB. Several Lamiaceae’s species such as Mentha piperita, Ocimum basilicum L., and Thymus vulgaris found active toward ESBL. Last, plants from Theaceae such as Camellia japonica and Camelia sinensis known actively tested toward CRE. In vivo tests existed are still related to MRSA through Dipterocarpus alatus, Apium graveolens, Garcinia mangostana, Plectranthus amboinicus (Lour.) Spreng, and Galla chinensis and CRE through Berberis aristata dan Camellia sinensis. The study shoud be explored, specifically for plant family that were analysed in this thesis.