KAJIAN PUSTAKA KOKRISTAL ANTIBIOTIKA DAN PEMBUATAN SISTEM MULTIKOMPONEN LEVOFLOKSASIN-ASAM SITRAT

• Main Author: Namira Laksana, Agnesya
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56685
• Institution: Institut Teknologi Bandung

Antibiotics are commonly used to treat infections caused by microorganisms. Based on the literature that has been reported, most of the antibiotics have poor physicochemical properties, especially their solubility. Solid materials engineering is an effort to improve the physicochemical properties of active ingredients without changing their original activity. One type of solid materials engineering is formation of multicomponent systems, such as cocrystals and salts. Levofloxacin is a fluoroquinolone class of antibiotics with a broad spectrum of action, poor water solubility, and is readily soluble in acidic conditions. On the other hand, citric acid has been reported to increase the solubility of other solids through the formation of cocrystal. The literature review aims to examine the development of antibiotics using the co-crystallization method and is followed by an experiment for making a levofloxacin-citric acid (LAS) multicomponent system to study the types of multicomponent systems formed and the characteristics of their physicochemical properties profile. The experimental involved screening for molar ratio, manufacturing of LAS, characterizing solids, and characterizing the physicochemical property profile. The literature review shows that the co-crystallization method is effective in developing antibiotics because it can improve the physicochemical properties of antibiotics, especially increase their solubility. Solid characterization using thermal analysis, Fourier Transform Infrared (FTIR), and Powder X-Ray Diffraction (PXRD) indicated the formation of a multicomponent LAS co-crystalline system with a molar ratio (1: 1). This is indicated by the melting point which is between the melting points of the two constituents; FTIR spectra showing band shift at wave numbers 2931- 2807 cm-1 and 1724cm-1 ; and the PXRD diffractogram showing new peaks at angles 2? = 4.98°, 9.9°, 11.24°, 12.52°, dan 15.64°. The results of the solubility assays showed an increase of levofloksasin solubility of 9.5 times in pH 6.8, 1.22 times in water, and 2.4 times in pH 1.2. LAS showed better flow properties and compressibility than levofloksasin alone.