KAJIAN PUSTAKA PENGEMBANGAN SISTEM PENGHANTARAN SUPEROKSIDA DISMUTASE SEBAGAI PROTEIN TERAPETIK

• Main Author: Shelvie
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56698
• Institution: Institut Teknologi Bandung

Free radicals are atoms that have unpaired electrons so it become unstable and highly reactive. To be stable, free radicals will take electrons from other molecules which can cause these molecules to become unstable and also cause damage to some cell components, so that antioxidants are needed to prevent overproduction of free radicals. Superoxide dismutase (SOD) is an antioxidant enzyme that can prevent the overproduction of free radicals that cause oxidative stress. However, the SOD delivery system has several disadvantages, such as large molecular weight, easily degraded in the digestive tract, and has a short half-life. Therefore, this study aims to conduct a literature review on the development of an SOD delivery system to maximize the therapeutic activity of SOD. The literature is obtained from search results on Google Scholar and is carried out with the keywords Superoxide dismutase, SOD, drug delivery system, formulation, therapeutic effect, and encapsulation. From the search results, there were 21 journals that met the search criteria. The results of a study of 21 journals show that the development of an SOD delivery system can use electrospun fibers, mucoadhesive chitosan-coated liposomes, PCL microparticles, zein nanoparticles and liposomes. The SOD delivery system with liposomes uses SA-liposomes (Stearylamine-liposomes) and PEG-liposomes (Polyethylene glycol-liposomes) to increase the therapeutic activity of SOD. SOD with SA-liposomes has better efficiency than SOD without liposomes. Modifications using PEG-liposomes showed that PEG-liposomes had longer therapeutic activity than SA-liposomes. In addition, a modification of hydrophobic SOD, namely Ac-SOD, was also made where Ac-SOD has a faster onset of therapeutic activity than SOD without modification.