LITERATURE REVIEW ON USING NANOPATTERNS AS A METHOD IN DIRECTING OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

• Main Author: Vanya, Katherine
• Format: Final Project
• Language: Indonesia
• Subjects: Ilmu hayati ; Biologi
• Online Access: https://digilib.itb.ac.id/gdl/view/57490
• Institution: Institut Teknologi Bandung

Severe bone damage can affect a person's quality of life because it can cause disability. Mesenchymal stem cells (MSCs) can be an alternative for bone healing because of their ability to regenerate tissue and immunomodulation. Stem cells grown on nanotopographic substrates (nanopatterns) can provide mechanical signals to MSCs for differentiation. This literature study aims to review nanopatterns in terms of their fabrication methods and their role in inducing MSC osteogenic differentiation, particularly in bone tissue engineering. Anodization is a method that is quite widely used in recent years because it is quite simple, and its diameter can be easily varied. This method usually produces nanotubes pattern and has been shown to increase the expression of MSC osteogenic markers, which indicates the differentiation process happens faster than on a flat surface. Nanopatterns combined with growth factors can increase the expression of osteogenic markers. The combination of growth factors with nanopatterns reduces the number of growth factors used while also reducing the risks they can cause. Nanopatterns can also be applied in scaffolds for tissue engineering so that the induced effects given by nanopatterns can persist even in the in vivo stage. Nanopatterns have huge potential in bone tissue engineering applications, so more research on nanopatterns still needs to be done for further development.