THE SELECTION OF NATURAL COMPOUNDS FROM INDONESIAN MEDICINAL PLANTS AS CANDIDATES OF AKT AND KRAS G12D INHIBITORS USING MOLECULAR DOCKING STUDY APPROACH
Resistance to anti-EGFR in colorectal cancer treatment may arise from the PTEN loss of function or KRAS G12D mutation. These events trigger the activation of EGFR major downstream signaling pathways which are PI3K-AKT or RAS-MAPK although the EGFR has been inhibited by anti-EGFR. Inhibition of these...
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| Format: | Theses |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/61265 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |