KAJIAN PUSTAKA FORMULASI SEDIAAN SEMI-SOLID DARI EKSTRAK KULIT BUAH RAMBUTAN (NEPHELIUM LAPPACEUM L.)
In recent years, there has been a growing interest in researching and utilization of rambutan peel (Nephelium lappaceum L.). Rambutan peel has been known for its high phenolic content and activity, such as antioxidant and antibacterial to protect skin from free radical and bacterial infection. Th...
Saved in:
| Main Author: | |
|---|---|
| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/61572 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | In recent years, there has been a growing interest in researching and utilization of rambutan
peel (Nephelium lappaceum L.). Rambutan peel has been known for its high phenolic content
and activity, such as antioxidant and antibacterial to protect skin from free radical and bacterial
infection. Through this literature review, antioxidant activity of rambutan peel extract (RPE)
was known by DPPH scavenging agent determination with IC50 = 8,668 µg/mL. While topical
antibacterial activity of RPE was determined by broth dilution with MIC = 3,2 mg/mL. In order to
attain its purpose of use, formulation semi-solid product of RPE has been developed, such as
cream and gel. Selection excipient and the amount of excipient can affect its physical
appearance, drug and product stability and permeability of drug. Therefore, formulation of
semi-solid product has to be reviewed and rationalized for optimization formula. Based on its
physical stability and appearance, RPE with concentration < 1,5% is best formulated in gel
preparation, whereas RPE with concentration ?1,5% is best formulated in cream preparation.
|
|---|