STUDI PUSTAKA PENGARUH PEMBENTUKAN KOKRISTAL KARBAMAZEPIN TERHADAP KELARUTAN DAN DISOLUSI DISERTAI SKRINING KOFORMERNYA SECARA IN SILICO
Carbamazepine is a class of first-line antiepileptic drugs commonly used to treat partial seizures, generalized tonic-clonic seizures, and trigeminal neuralgia. As a BCS (Biopharmaceutical Classification System) class II drug, carbamazepine has poor solubility. This can affect the dissolution rat...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/61822 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Carbamazepine is a class of first-line antiepileptic drugs commonly used to treat partial seizures,
generalized tonic-clonic seizures, and trigeminal neuralgia. As a BCS (Biopharmaceutical
Classification System) class II drug, carbamazepine has poor solubility. This can affect the
dissolution rate and have an impact on poor bioavailability. The formation of cocrystals with
suitable coformers can be an alternative to overcome these problems. However, the experimentalbased cocrystal screening method is considered less effective and efficient so that the
computational method can be a profitable choice. In this study, coformers screening that have the
potential to form cocrystals with carbamazepine was carried out using Mercury 2020.2.0 software
from the Cambridge Structural Database (CSD) based on molecular complementarity and hydrogen
bonding propensity. In addition, a literature study has been carried out regarding the possibility of
carbamazepine cocrystals in improving their solubility and dissolution rate. Based on the analysis
of the results of coformer screening and literature review, it was found that benzamide as the most
potential coformer to increase the solubility and dissolution profile of carbamazepine.
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