KAJIAN PUSTAKA POTENSI PENGGUNAAN BIOSURFAKTAN DARI MIKROBA SEBAGAI EMULGATOR DALAM SEDIAAN EMULSI

• Main Author: Fakhirahusna, Ghina
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/61931
• Institution: Institut Teknologi Bandung

Emulsions are one of the most used pharmaceutical dosage forms, where an emulsifier is needed to stabilize the system, and surfactants remain the most popular choice due to their effectiveness. Most surfactants are chemically synthesized and have poor biodegradability and biocompatibility, which lead to the development of biosurfactants, which are surfactants that are produced by microorganisms. In this review, the methods of production, purification, and formulation of biosurfactants in emulsions are studied. A systematically literature search was conducted on four database sites, which were PubMed, Science Direct, Wiley Online Library, and Google Scholar. Sixty-four articles passed the inclusion criteria which then further analyzed. It was found that glycolipids and lipopeptides were the most produced biosurfactants from bacteria, the most studied bacteria were Pseudomonas sp., and Bacillus sp., the most common method of biosurfactant production was microbial fermentation, and the highest purity was obtained through solvent extraction method and chromatography. The emulsions that were formulated were oil-in-water emulsions and nanoemulsions for topical use, cosmetics, and food formulations. From the evaluations, it was found that biosurfactants did not influence the rheology of emulsions, could lower the surface tension, while the stability was influenced by pH and ionic concentrations, but not influenced by temperature.