ANTIINFLAMMATORY ACTIVITIES OF A COMBINATION OF TURMERIC (CURCUMAE LONGAE RHIZOMA) AND BLACK PEPPER (PIPERIS NIGRI FRUCTUS) IN WISTAR RAT (RATTUS NORVEGICUS)
Turmeric is a spice that has been known for a long time and has attracted the interest of the medical world because of its properties. Most of the benefits of turmeric related with antioxidant and anti-inflammatory effects, but consuming turmeric alone is less beneficial due to its poor bioava...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/61960 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Turmeric is a spice that has been known for a long time and has attracted the
interest of the medical world because of its properties. Most of the benefits of
turmeric related with antioxidant and anti-inflammatory effects, but consuming
turmeric alone is less beneficial due to its poor bioavailability, mainly due to its
poor absorption of active substances, fast metabolism and elimination. There are
several substances that can increase bioavailability, including piperine which is the
active component of black pepper. This study aims to examine the antiinflammatory properties of acute and chronic combination of turmeric and black
pepper powder. Two combined doses were tested i.e combination A (turmeric/black
pepper = 205,2 / 10,8 mg/kg bw) and combination B (turmeric/black pepper =
136,8 / 7,2 mg/kg bw). Anti-inflammatory effects were tested on Wistar rats which
included acute anti-inflammatory effects with ? -carrageenan as inductors and
chronic anti-inflammatory effects with Freund's Complete Adjuvant as inductors.
In the acute anti-inflammatory test, single powdered turmeric (205,2 mg/kg bw) did
not showed significant anti-inflammatory activity,but the A combination could
trigger inflammation significantly (p<0.05) at the 4th
, 6
th
, 8
th and 24th hour 47,0 ;
27,6 , 25,1 and 36.1%. On chronic anti-inflammatory test, the two combinations (A
and B) did not show chronic anti-inflammatory base on parameters i.e., body
weight, paw volume, joint and paw thickness, local hyperthermia, mobility,
maximal arthritis index and joint stiffness, TNF-a and IL-17A serum titers.
Combination A can reduce Nitric Oxide levels (p<0.1), and combination B can
significantly reduce Anti-Cyclic Citrullinated Peptide Antibody (anti-CCP) levels
(p<0.05). The results of determining anti-CCP levels provide an overview of the
safety of using a combination of turmeric powder and black pepper as an antiinflammatory |
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