UJI TOLERANSI GLUKOSA DARI FRAKSI DAUN KATUK (SAUROPUS ANDROGYNUS (L.) MERR.) DAN STUDI LITERATUR MENGENAI FRAKSI TANAMAN YANG BERPOTENSI SEBAGAI SENYAWA ANTIDIABETES

• Main Author: Theresia, Kristin
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/61963
• Institution: Institut Teknologi Bandung

Diabetes mellitus is one of the diseases with a high prevalence in Indonesia. Pharmacological and nonpharmacological therapy can be a choice for treating diabetes mellitus. However, therapy with conventional drugs often caused side effects. Therefore, there is still another chance for another alternative treatment, such as medicinal plants. This research aims to know the effect of fractions 1 and 2 from katuk leaves in reducing blood glucose on glucose tolerance test. A literature study is also being done to know which plant fractions could potentially be an antidiabetic agent. The doses of fraction 1 and 2 were 100, 200, and 400 mg/kg BW each. Test samples, solvents, or standard drugs were given 30 minutes before glucose administration. Blood glucose levels were measured 30, 60, 90, 120, 150, and 180 minutes after glucose administration. A literature study was conducted by searching through Pubmed and Science Direct. The glucose tolerance test results showed that the blood glucose levels of the fraction 2 group at 100 mg/kg were significantly different (p<0,05) from the positive control group at t30, t150, and t180. From literature study, there are 26 journals and 28 plants that have been obtained for further analyzed. Based on the glucose tolerance test results, it could be concluded that fraction 2 with a dose of 100 mg/kg could prevent an increase in blood glucose levels. Based on the literature study results, it can be concluded that the ethyl acetate fraction was the most used and showed the most blood glucose levels decrement.