UJI EFEK ANTISPASMUS EKSTRAK ETANOL RIMPANG JAHE EMPRIT (ZINGIBER OFFICINALE ROSC. VAR. RUBRUM) PADA TIKUS WISTAR JANTAN DENGAN METODE SPINAL CORD INJURY

• Main Author: Wulansari, Harina
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/62197
• Institution: Institut Teknologi Bandung

Background and objectives: Muscle cramps are condition where there are sudden muscle contractions that cause pain and discomfort, usually lasts for a few seconds to few minutes. Cramps have a high incidence in the community. A previous study states that 95% patients with excessive activity suffered from muscle cramps. In a more recent studies states that 35-60% in a group of elderly suffer cramp where 40% having cramps more than three times a week. Quinine is widely used as a pharmacological therapy to control cramps. However, in 1995 the use of quinine to combat cramps are not allowed by the FDA (Food and Drug Administration) because of too high side effect and the risk-benefit ratio of quinine is too high. Therefore, this study will test the effects of ginger antispasmus in male Wistar rats. Methods: Powder of ginger rhizome was extracted with ethanol by reflux. Cramp model in mice was created by the spinal cord injury method, which is done by creating a lesion on the sacratum and then evaluated each week to determine the spasmus score with a swimming test. The test animals were divided into 6 groups consisting of the positive control group (0.5% Na CMC), the oral quinine 26 mg/kg bw, topical quinine 0.1 g, oral ginger 100 mg/kg bw, oral ginger 200 mg/kg bw and topical ginger 0.2 g. The product was given on the 6th day after spinal cord injury every day for 6 weeks. Results: Oral ginger of 100 mg/kg bw and 200 mg/kg bw showed an inhibition of the progression of muscle spasms. Inhibition of the progression of muscle spasms can be seen in acute conditions (week 1) and in chronic conditions (week 5 to week 6). The oral ginger of 200 mg/kg bw gave significantly different results at week 6 compared to the positive control group. Conclusion: The use of ginger 100 mg/kg bw and 200 mg/kg bw orally produces antispasmus effect with lesser side effects compared to the use of quinine at a dose of 26 mg/kg bw.