UJI STABILITAS KURKUMIN DARI SEDIAAN KAPSUL YANG MENGANDUNG CAMPURAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRIZA ROXB.) DAN JATI BELANDA (GUAZUMA ULMIFOLIA LAMK.VAR.TOMENTOSA SCHUM)

• Main Author: Hidayati, Nurul
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/62211
• Institution: Institut Teknologi Bandung

Curcuma xanthorriza contains various chemical compounds such as curcumin that its stability properties are highly influenced by the environment. The aim of the study was to determine the stability of curcumin through accelerated stability test. Crude drug of Curcuma xanthorriza was extracted using ethanol and 96% for 4 days with solvent replacement every 24 hours. The ethanol extract Curcuma xanthorriza obtained was concentrated by rotary vaporator. While, crude drug of Guazuma ulmifolia was extracted through the production of infusum. Guazuma ulmifolia extract was dried using freeze dryer. Curcuma xanthorriza extract was mixed with Guazuma ulmifolia extract at the portion 1 : 1. The mixture of extract was added of the Avicel with the same portion and Aerosil as much as 2 %. This mixture was threated by wet granulation using starch paste as binder. Granule obtained was filled into the capsule shell size of 00. Capsules was put into the climatic chamber at a temperature of 40 o C ± 2 o C and humidity 75% ± 5%. The concentration of curcumin was determined after 0 days, 2 weeks, 1 month, 1.5 months; two months after storage. The stability observation included physical appearance, moisture content, disintegration time, dissolution and content of curcumin in a capsule. The mixture of extract was hygroscopic compound because the moisture content increased up to 9,76 % after two months testing. Curcumin was decomposed up to 21 % after the two-month testing. Curcumin was unstable at the testing condition.