FABRICATION OF POLYVINYL PIRROLYDONE (PVP)/VIRGIN COCONUT OIL (VCO) COMPOSITE FIBERS USING ROTARY FORCESPINNING FOR DRUG DELIVERY APPLICATION

• Main Author: Priyanto, Aan
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/62494
• Institution: Institut Teknologi Bandung

Virgin Coconut Oil (VCO) has been widely used for biomedical applications due to their fatty acids and bioactive compounds. Bioactive compounds, such as, tocopherol, tocotrienol, retinol, stigmasterol, and phystostanol have antioxidant properties which are widely applied for drug delivery applications. Recently, VCO utilization for drug delivery application is generally carried out by direct supplementation or in the form of composite solutions, thin films, lotions, and emulsions. Fiber-based VCO encapsulation is a very promising research, because fiber feature small diameters (nanometers or micrometers), high surface area per volume ratio, high drugs loading capacity, and allow controlled release of drug molecules. This study aims to encapsulate VCO into polyvinyl pyrrolidone (PVP) matrix using the rotary forcespinning (RFS) technique. Parameter optimization using Box-Behnken Design (BBD) experiment used to obtain the optimum parameters for producing PVP/VCO composite fibers. PVP/VCO composite fibers with a diameter of (1.28 ±0.06) – (2.17 ±0.41) ?m have been fabricated using 10 wt.% PVP solution, rotational speed of 11450 rpm, collector distance of 20 cm, and addition of 8 wt.% VCO solution with various weight ratios (PVP:VCO) of 10:2, 10:3, 10:4, and 10:5. FTIR analysis showed that the FTIR spectrum of the PVP/VCO composite fiber was similar to the FTIR spectrum of pure VCO samples containing phenolic groups, indicating the successful encapsulation of VCO into the PVP matrix. XRD analysis denoted that the PVP/VCO fiber composite was amorphous with a diffraction pattern indicating the successful encapsulation of VCO into the PVP matrix. The antioxidant test results showed that the encapsulation of VCO into PVP fiber did not significantly alter the antioxidant activity of VCO. Moreover, according to the release test, the release of VCO from PVP/VCO composite fibers was affected by the fiber diameter. The small diameter results in a release profile which dominated by continuous/sustainable release processes. This shows that the encapsulation of VCO into PVP fibers can control the release of VCO which is very beneficial for drug delivery system.