CONDUCTIVE POLYMERIC-BASED ELECTROACTIVE SCAFFOLDS IN TISSUE ENGINEERING: SYNTHESIS, FABRICATION, AND ELECTRICAL STIMULATION
Electroactive scaffolds and the delivery of electrical stimuli have a positive and potentially great effect on cellular activities, thus attracting attention in their application in tissue engineering. Polyaniline (PANI) which is a conductive polymer (CPs) allows it to be applied as a composite s...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/62520 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Electroactive scaffolds and the delivery of electrical stimuli have a positive and
potentially great effect on cellular activities, thus attracting attention in their
application in tissue engineering. Polyaniline (PANI) which is a conductive
polymer (CPs) allows it to be applied as a composite scaffold that has conductive
properties. In this study, PANI was synthesized by chemical oxidation method and
mixed with Polycaprolactone (PCL) through manual physical melt blending
method. The resulting PANI and PCL/PANI were characterized by means of
Fourier Transformation Infrared Spectroscopy (FTIR) and X-ray Diffraction
(XRD) to confirm the successful formation of PANI and mixing of PANI to PCL.
The PCL/PANI polymer composite will be fabricated into an electroactive scaffold
using the screw-assisted extrusion-based 3D printing method. Therefore, a
modification of the commonly available filament-based 3D printing tool into a
pellet-based screw-assisted extrusion 3D printing tool is proposed. After
conducting a literature review, a suitable modification design proposal is
submitted. In addition, the effect of electrical stimulation on the CPs-based
electroactive scaffold and the parameters involved were also studied so that the
design and initial set-up of the electrical stimulation process on the PCL/PANI
electroactive scaffold was determined. Finally, will be discussed the latest progress
on the utilization strategy and the advantages of using CPs as electroactive
scaffolds in tissue engineering. The use of CPs with other materials in electroactive
scaffolds through several strategies showed enhancing of the mechanical
properties, hydrophilicity, biocompatibility, biodegradability, and conductivity of
the electroactive scaffold. |
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