PENGAMATAN PENGARUH PELARUT DAN PEMANASAN TERHADAP STRUKTUR BAHAN BAKU OBAT SIPROFLOKSASIN BASE DAN GARAM HCL-NYA
Antibiotics are generally used to treat and prevent infections caused by bacteria. Antibiotics as one of the active pharmaceutical compounds can be present in various solid forms which are divided into crystalline forms and amorphous forms. In the form of amorphous and crystalline, solid drugs can...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/62975 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Antibiotics are generally used to treat and prevent infections caused by bacteria. Antibiotics as one of
the active pharmaceutical compounds can be present in various solid forms which are divided into
crystalline forms and amorphous forms. In the form of amorphous and crystalline, solid drugs can be in
the form of anhydrous or solvate/hydrate which are commonly called pseudo polymorphs. Pseudo
polymorphs generally show differences in physicochemical properties including stability, solubility,
density, dissolution rate, and bioavailability. Changes in the shape of the pseudo polymorphs can be
influenced by mechanical factors (such as the granulation process, grinding, pressure) and
environmental factors (such as increased temperature and humidity). The research was conducted by
observing the hydrate transformation of ciprofloxacin base (SB) and ciprofloxacin HCl (SH) after being
heated at 100°C and the effect of various compositions of methanol-water solvent on the resulting
hydrate form. Sample characterization was carried out by electrothermal analysis, microscope
observation, FTIR, DSC, and PXRD. The experimental results showed that heating at a temperature of
100°C in SB and SH resulted in the transformation into anhydrous form with different heating times,
namely heating for 3 hours for SB and 2 hours for SH. Recrystallization of SB and SH with various solvent
compositions produces needle crystals. The starting material for SB is in the same monohydrate form
as 20% methanol recrystalite, while in 80% and 50% methanol it is in the hemihydrate form. The result
of recrystallization of SH with methanol and water it produces a monohydrate form, and at 50%
methanol produces a sesquihydrate form.
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