CHARACTERIZATION OF MICROENCAPSULATION IBUPROFEN WITH GELATINE-FORMALDEHYDE CROSS-LINKING TECHNIQUE

• Main Author: Octaviani (NIM 107 03 015), Linda
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/6397
• Institution: Institut Teknologi Bandung

Abstract : <br /> <br /> <br /> <br /> Ibuprofen is a nonsteroidal anti-inflammatory drug, an acidic compound, and causes irritation on gastric after oral administration. A formulation strategy to eliminate this adverse effect is by microencapsulation technique. The objective of this study is to develop ibuprofen - loaded microcapsule with formaldehyde crosslinked gelatine. Parameters influencing the microcapsule characteristic such as particle size and particle size distribution, particle morphology, drug loading capacity, and release profile of ibuprofen from microcapsules were studied. The release study of ibuprofen from microcapsule was performed with USP apparatus 2, at maintained temperature of 37 C +/- 0.5 C, 100 rpm, in 900 mL of mediums (hydrochloric acid at pH 1.2 and phosphate buffer at pH 7.2). Results showed that stirring speed, ibuprofen : gelatin ratio, and hardening time influenced the microcapsule characteristic. Microcapsule with good characteristic resulted in this study was microcapsule prepared with stirring speed of 250 rpm, ibuprofen : gelatine ratio of 1:1, and hardening time of 3 hours. The release of ibuprofen from microcapsule in pH 1.2 hydrochloric acid after 2 hours was 14.82% and 6.32% for various ratio of ibuprofen : gelatine concentration 1:1 and 1:1.5 respectively. In contrast, the release in the phosphate buffer at pH 7.2 was respectively 96.41% and 91.54%. Based on these results, it was concluded that formaldehyde - crosslinked gelatine microcapsule containing ibuprofen retained the release of drug in gastric fluid simulation while showing sustained-release profile up to 24 hours in intestine fluid simulation.