FORMULASI TABLET GRANULASI BASAH TERKOMPUTERISASI

• Main Author: Hartono Adiputro, Eko
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/64304
• Institution: Institut Teknologi Bandung

Background and Objective. Tablet is one of solid pharmaceutical product that contain active ingredient with or without the presence of excipient. One of the famous method that frequent used in tablet formulation desain is empiric method. Empiric method has several disadvantage such as it takes lot of time to collect preformulation data and produce many alternative formula for one similar active ingredient. Method. Prefonnulation data collection based on laboratory experiments and literature. Laboratory experiments included measuring PVP K-25 bonding ability to form granule, tablet lubricant component (magnesium stearate and lauric acid) for lubricating, crushing properties of tablet disintegrant (sodium alginate, Amprotab, Avicel PH102, Primogel, and Starch 1500), tablet filler (Avicel PH102, dextrin, maltose, and dextrose) against flowability and compressibility mixture of tableting powder. Acquired preformulation data then used in the development of tablet formulation model. Result. Paracetamol tablet model contained paracetamol, PVP-K25, Amprotab, magnesium stearate, talc and Avicel PH-102. Evaluation type of tablet conducted were hardness, friability, friction, mass equality results are 5.5 N/Cm2; 0.91 %; 0.89 %; 302 + 3 mg. Conclusion. The design of paracetamol tablet model could produce qualified paracetamol tablet.