STUDI KOMPARATIF PENINGKATAN LAJU DISOLUSI PIROKSIKAM AKIBAT PEMBENTUKAN DISPERSI PADAT DENGAN BERBAGAI PEMBAWA

• Main Author: Purpika, Chandra
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/64337
• Institution: Institut Teknologi Bandung

Piroxicam is a nonsteroidal anti-inflammatory drug which is generally used for osteoarthritis and rheumatoid arthritis. Piroxicam possesses low solubility and high permeability. There are many methods to improve solubility, one of them is by making solid dispersion. The aim of this study is to increase the dissolution rate of piroxicam by formation of solid dispersion with PEG 4000, PEG 6000 dan PVP K-25. Solid dispersions of piroxicam were prepared with PEG 4000 and PEG 6000 by fusion and solvent method with weight ratio between piroxicam and PEG 4000/ PEG 6000 1:1; 1:2 and 1:3. Solid dispersions of piroxicam with PVP K-25 were prepared by solvent method with weight ratio between Piroxicam and PVP K-25 1:1 and 1:2. To compare the result of solid dispersions, nanodispersion wasmade with precipitation method. Dissolusion test was conducted by using type 2 apparatus (paddle method) with HC1 pH 1,2 medium. Bath temperature and paddle rotation speed were set at 37°C and 50 rpm. Drug : carriers interaction of solid dispersions and physical mixtures were characterized by FTIR. The dissolution rate from solid dispersion of piroxicam and PVP K-25 1:2 increased 6,2 times compared to the pure drug in 10 minutes and showed better dissolution profile when compared to the formation of solid dispersions with other carriers. Solid dispersion of piroxicam with PVP K-25 as carrier could release almost 100% within 45 minutes. Formation of solid dispersions using various carriers with certain weight ratio can improve the dissolution rate of piroxicam. Solid dispersion which was prepared with PVP K-25 showed the best dissolution rate.