PENGEMBANGAN FORMULA NANOEMULSI EKSTRAK METANOL URANG ARING (ECLIPTA ALBA L.HASSK) DENGAN MINYAK KELAPA MURNI (VIRGIN COCONUT OIL) DAN MINYAK KEMIRI SERTA UJI AKTIVITAS IN VIVO PADA TIKUS WISTAR JANTAN

• Main Author: Gadri, Mutia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/64338
• Institution: Institut Teknologi Bandung

Urang aring use in generally by applying urang aring water or oil extracts to the scalp. Formulation of urang aring in the form of nanoemulsions aims to improve the effectiveness of urang aring as hair growth promotion. Nanoemulsions were made using Vigrin Coconut Oil (VCO) or candlenut oil as the oil phase, Tween 80 as surfactant and glycerin as cosurfactant. Optimization process were done for preparation method, ratio of surfactant-cosurfactant and the percentage of each component in the formula to obtain stable nanoemulsions during the storage. The evaluation of nanoemulsion consist of organoleptic, pH, tyndall effect, density and viscosity, physical stability tests using centrifugation and freeze-thaw methods and in vivo activity test for hair growth was done for 21 days in male Wistar rat. The elongation of hair growth was measured after 7, 14 and 21 days of administration respectively and the hair density was measured at days 21'11 by weighing of hair in each area of preparations is utilized from each group. Result for organoleptic observation showed that nanoemulsions had a green color appearance. There were no phase separation occured after centrifugation test and after 28 clays of storage at room temperature. In freeze-thaw stability test nanoemulsions had significant increase of globule size for every each cycle and phase separation was observed after fifth cycle. The preparations had viscosity 27.5 cps and 37.5 cps for nanoemulsion VCO (NV) and candlenut (NK) respectively with an average pH of 5.94. Comparison of hair growth test between each group showed that the percentage of hair growth in both types of nanoemulsions (NV and NK) were better than its given by other groups such as group of base nanoemulsions (BV and BK), extract urang aring in both oil (MV and MK) and extract urang aring in ethanol (E) . The preparation of NV and NK showed higher percentage of hair growth (26.9%; 28.39%) after 7 days, (37.58%; 31.85%) after 14 days and (43.57%; 20.46%) after 21 clays respectively compared to the result obtained from extract urang aring in oil (MV and MK). Nanoemulsions of NV and NK also showed higher percentage of hair growth compared with extract urang aring in ethanol (E) after 7 days (43%; 43.7%), 14 days (43.7%; 31.85%) and 21 days (52.07%; 21.89%) respectively. But in the study of hair density promotion by measuring the weigh of hair in each test area of the group, only nanoemulsion of NV showed significant increase in number of hair density compared to E and K whereas with other preparations the differences are not significant. In conclusions, both of nanoemulsions (NV and NK) had good activity to promote of hair growth and nanoemulsion NV was also showed the ability to improve hair density.