EFEK ANTIDIABETES DAN ANTIAGREGASI PLATELET EKSTRAK ETANOL BUAH KETUMBAR (CORIANDRUM SATIVUM L.) PADA MENCIT DIABETES ALOKSAN

• Main Author: Azzahra, Fatimah
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/64798
• Institution: Institut Teknologi Bandung

Platelets hyperaggregation and hyperactivation conditions also occurred in most patients with diabetes mellitus which increase the risk of cardiovascular complications. In Indonesia, coriander fruit is widely used for treating diabetes mellitus. Pharmacological effects of coriander fruits that have been proven are antidiabetic and thrombolytic effects in vitro. The purpose of this study was to investigate platelet antiaggregation and antidiabetic effects of the ethanolic extract of coriander fruit. In glucose tolerance method, blood glucose level was measured every 30 minutes for 2 hours after oral administration of glucose solution 3 g/kg bw with glibenclamide 0.65 mg/kg bw as comparator drug. In alloxan-induced diabetic mice, platelet antiaggregation effects test, blood glucose level, bleeding time and coagulation time was measured on days 0, 1, 3, 6 and 9 at 0 and 2 hour after the administration of test materials. Blood glucose level was measured using Easy Touch'. Glucose tolerance method showed that the ethanolic extract of coriander group with 140 mg/kg bw dose had a higher percentage change in blood glucose levels compared to coriander group with 280 mg/kg bw dose. Significantly different (p<0.05) changes in blood glucose levels (expressed as percentage of To) compared with the control group was shown by glibenclamide group (0.65 mg/kg bw) on Tim and T150. In alloxan diabetic mice method, significantly different (p<0.1) percentage change in blood glucose levels compared with the blood glucose level of control group were shown by glibenclamide group (0.65 mg/kg bw) on H3T0, H3T2, H6T0, H6T2 and H9T2, and the ethanolic extract of coriander group (140 mg/kg bw) on H1T2 and H3T0. Significantly different (p<0.1) percentage changes in bleeding time with control group were shown by the aspirin 20.8 mg/kg bw group on H0T2 and coriander group (280 mg/kg bw) on HITE. Significantly different (p<0.1) percentage changes in coagulation time with control group were shown by coriander group (140 mg/kg bw) on H0T2, H1T2, and H6T2 and coriander group (280 mg/kg bw)on H6T2 and H9T2. Based on the glucose tolerance test and alloxan diabetes data, ethanolic extract of coriander fruit has an acute effect on lowering blood glucose levels. In long term administration, the decrease in blood glucose levels is not statistically significant compared with the initial blood glucose levels. Hyper-aggregated platelets were formed on alloxan diabetic mice only on 72 hours after induction. The platelet anti- aggregation effects test indicates that the ethanolic extracts of coriander fruit are not able to increase bleeding and coagulation time continuously in the test subjects during therapy (9 days).