AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SYZYGIUM JAMBOS DAN SYZYGIUM MYRTIFOLIUM MENGGUNAKAN METODE UJI TOLERANSI GLUKOSA ORAL PADA MENCIT

• Main Author: Amalia Mulyadi, Frieda
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/65112
• Institution: Institut Teknologi Bandung

Diabetes mellitus is one of the non-communicable diseases causing death globally and is a metabolic disease characterized by the condition of hyperglycemia or high blood glucose levels due to impaired insulin work. Herbal medicine from various types of plants has been used for a long time to prevent, diagnose, and treat diseases. Two of the plants that are widely spread in Indonesia are jambu mawar (Syzygium jambos) and pucuk merah (Syzygium myrtifolium). Jambu mawar has benefits in overcoming constipation and antidiabetic activity. Pucuk merah has benefits in overcoming abdominal pain and also has antidiabetic activity. Research on the prevention of increased blood sugar levels for both plants is rarely done, so this study aims to determine the antidiabetic activity to prevent increased blood glucose levels using glucose tolerance test methods in vivo. The glucose tolerance test is performed with all mice were fasted then the initial blood glucose levels are measured. Then all groups were given a test preparation and continued with maltose administration. Blood glucose levels are measured every 30 minutes after maltose administration until the 180 minute. The study found that S. jambos and S. myrtifolium contains flavonoid, tannins, and steroids/triterpenoids. Meanwhile, saponins only found in S. jambos. It was also found that the total flavonoid content for S. myrtifolium is lower than S. jambos. TLC showed that both extracts have flavonoid compounds. In vivo test results showed both plants at all three doses of administration have the antidiabetes activity increased blood glucose level prevention.