AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL PHYLLANTHUS EMBLICA L. DAN MYRMECODIA BECCARII HOOK.F. PADA KONDISI HIPERURISEMIA AKUT DAN KRONIS SECARA IN VIVO

• Main Author: Nurul Fauziah, Popy
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/65114
• Institution: Institut Teknologi Bandung

The prevalence of gout in Indonesia is ± 18%. Indonesia has a biodiversity that has the potential as medicinal plants, one of which is the potential to reduce uric acid levels. In this study, tests were conducted for plants with the potential to have uricostatic antihyperuricemic activity, namely malacca (Phyllanthus emblica L.) and ant nest (Myrmecodia beccarii Hook.f.). The study began with the phytochemical screening of the two extracts. Then the determination of flavonoid levels and thin-layer chromatography (TLC). In vivo testing was performed using male Wistar rats using acute and chronic hyperuricemia modeling. The condition of acute hyperuricemia is carried out by giving extracts and drugs in one administration. Meanwhile, extracts and drugs are given repeatedly for 14 days for chronic hyperuricemia. This study found that the phytochemical screening of P. emblica contained flavonoids, tannins, saponins, triterpenoids and alkaloids. Meanwhile, M. beccarii contains flavonoids, tannins, quinones, and steroid. In determining flavonoid content, the results showed in the ethanol extract sample of M. beccarii had lower total flavonoid content than P. emblica. In the TLC test, it was seen that there were flavonoid group compounds in both extracts. In in vivo testing of acute hyperuricemia conditions at 150 minutes the samples of P. emblica 150, 300 mg/kgBW and M. beccarii 300 mg/kgBW differed significantly with positive controls. Meanwhile, in the chronic hyperuricemia on day 28, only P. emblica 150 mg/kgBW and M. beccarii 150 mg/kgBW samples had a significant difference from the positive control.