EFEK ANTIAGREGASI PLATELET EKSTRAK AIR BULBUS BAWANG PUTIH, EKSTRAK ETANOL RIMPANG KUNYIT, JAHE MERAH, DAN BUAH MENGKUDU SERTA KOMBINASINYA PADA MENCIT JANTAN GALUR SWISS WEBSTER

• Main Author: FITRIYANI , NURUL
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/6571
• Institution: Institut Teknologi Bandung

Antiplatelet aggregation effect of garlic (Allium sativum L.) water extract, turmeric (Curcuma domestica Val.) ethanol extract, ginger (Zingiber officinale Rosc. var Sunti Val.) ethanol extract, noni fruits (Morinda citrifolia L.) ethanol extract and its combination to Swiss Webster mice has been investigated. The sample and Acetosal as reference Substance which suspended in 0.5 percent Carboxymethylcellulose Sodium, and also 0.5 percent Carboxymethylcellulose Sodium suspension as control given orally during the period of 28 days. Antiplatelet aggregation effect was tested by measuring bleeding time, coagulation time, and decreasing plasma absorbance to observe platelet aggregation activity before and after addition of ADP as platelet aggregation inducer. The result showed that noni fruits extract at a dose of 100 mg/kg body weight, ginger extract at a dose of 50 mg/kg body weight, combination of noni fruits and ginger extract at dose of each 100 and 50 mg/kg body weight and also 50 and 25 mg/kg body weight, turmeric extract at dose of 100 mg/kg body weight, garlic extract at a dose of 100 mg/kg body weight, combination of turmeric and garlic extract at a dose of each 100 mg/kg body weight and also 50 mg/kg body weight increased bleeding time, coagulation time, and decreased plasma absorbance which indicate that there was inhibition of platelet aggregation. The test substances above increased bleeding time with percentage of bleeding time increase were more than 400 percent (p less than 0,05). The percentage of coagulation time increase were more than 35 percent. The percentage of plasma absorbance decrease were more than 60percent for each extract. There was no significantly differences beetwen single and combination extract in increasing bleeding time, coagulation time, and inhibition of platelet aggregation .