POLYCAPROLACTONE-CARBONATE HYDROXYAPATITE COMPOSITE AS ALVEOLAR BONE SCAFFOLD CANDIDATE

• Main Author: Damayanti, Herlina
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/67396
• Institution: Institut Teknologi Bandung

Alveolar bone defects can repair through bone tissue engineering using the porous scaffold. In this study, the scaffold based on polycaprolactone-carbonate hydroxyapatite (PCL/CHA) composite has been successfully fabricated using the salt leaching method as a biomaterial candidate for alveolar bone tissue regeneration. CHA that is used in the scaffold fabrication was obtained from dry milling of hydroxyapatite based on Indonesian natural limestone from the center for ceramics (HA-BBK) with magnesium carbonate (MgCO3). Type-B CHA was successfully synthesized by the dry milling method at low speed (200 rpm) and the fastest time was one hour. The addition of CHA into the PCL matrix was 1% and 10%. PCL/CHA scaffolds produce heterogeneous pore sizes (small pores ?40 ?m and large pores 100-400 ?m) and pore interconnectivity that qualifies as alveolar bone scaffolds. The decrease of the scaffold hydrophobicity occurred along with the addition of CHA. PCL/CHA scaffold showed non-toxic and supported the proliferation of osteoblasts. The bioactivity of the scaffold was characterized by the formation of an apatite layer on the surface of the scaffold after immersion in SBF solution. Based on the characterization results, it is shown that the PCL/CHA scaffold has the potential to be applied to repair alveolar bone defects.