CAFFEINE DERIVATIVES AS ANTIBACTERIA AND CASPASE-3 INHIBITORS
Caffeine (1) is a derivative of xanthine which is popularly known in beverages and its function is as a stimulant to the central nervous system which has the effect of increasing concentration, focus and relieving drowsiness. In addition to the use of caffeine (1) in the form of beverages, recently...
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| Format: | Theses |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/68058 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Caffeine (1) is a derivative of xanthine which is popularly known in beverages and its function is as a stimulant to the central nervous system which has the effect of increasing concentration, focus and relieving drowsiness. In addition to the use of caffeine (1) in the form of beverages, recently there have been developing sources of caffeine in pure powders that are sold freely, so that caffeine (1) is easily accessible as a chemical. So research related to caffeine (1) for other uses is also growing. One of the developments of caffeine (1) is by modifying or chemically transforming it. In addition, caffeine (1) is reported and known to have biological activities such as anti-inflammatory, antidiabetic, antibacterial, and enzyme inhibitors. In this study, caffeine (1) was reacted with selectfluorTM (2) to obtain fluorocaffeine (3) which was further reacted with a secondary amine. Four transformed compounds were produced, namely butylaminecafeine (4), ethylaminecafeine (5), benzylaminecafeine (6), and methoxybenzylaminacafein (7). The five compounds were tested against 4 bacteria, namely B. subtilis, S. aureus, S.typhii and P. aeruginosa and their activity was tested against the caspase-3 enzyme. The results of the antibacterial activity test showed that compounds 4 to 7 provided an inhibition zone, but only compound (7) in P. aeruginosa bacteria gave a significant inhibition zone of 10.5 mm, close to the inhibition zone values of positive control chloramphenicol of 14.5 mm. The results of the caspase-3 enzyme activity test showed that compound (4) and compound (7) gave inhibition values of 11% and 20%, respectively, which were included in the weak category when compared to the standard, namely Z-VAD-FMK which gave 100% inhibition. Based on these results, all the amine-cafein derivative compounds produced have antibacterial potential and also caspase-3 enzyme inhibitor compounds, especially compound 7. |
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