PRELIMINARY STUDY OF SYNTHESIS AND CHARACTERIZATION OF ASIATICOSIDE IMPRINTED POLYMER FROM METHACRYLIC ACID AND ETHYLENE GLYCOL DIMETHACRYLATE

• Main Author: Savitri, Sarah
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/68064
• Institution: Institut Teknologi Bandung

The medicine and cosmetics industries are currently expanding pretty quickly and are of concern in Indonesia. Centella asiatica, often known as gotu kola leaf, is one component that is currently gaining attention from the public. The largest constituent in C. asiatica is asiaticoside which can accelerate wound healing and delay premature aging. With these advantages, asiaticoside extraction from C. asiatica has gained popularity. Numerous techniques have been used to separate and determine asiaticoside from C. asiatica, but none of them have used molecularly imprinted polymer (MIP). A synthetic polymer called MIP has binding sites that were developed based on a certain template. Functional monomers play a significant part in the production of MIP. MIP is a synthetic polymer containing binding sites produced based on a particular template. Functional monomers play a significant part in the production of MIP. Methacrylic acid is one of them because it contains a carboxylic group that allows it to interact with the asiaticoside alcohol group. Methacrylic acid and ethylene glycol dimethacrylate were used as the building blocks to create MIP and NIP in this work. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were used to characterize MIP and NIP. The efficacy of MIP and NIP was evaluated using samples of synthetic asiaticoside. Based on the area/height of the chromatogram peak, the contact time variation test results showed that the adsorption of asiaticoside for MIPL-D was 8,73%/-7,65% at the ideal time of 180 minutes, for MIPL-M it was up to 27,29%/33,92% at 60 minutes, and for NIP it was up to 22,17%/25,66% at 180 minutes. Based on the area-height of the chromatogram peak, the polymer mass variation test results indicated that the adsorption of asiaticoside for MIPL-D was 20,06%/18,98% at an ideal mass of 50 mg. For MIPL-M and NIP, meanwhile, the ideal polymer mass was not attained.