EVALUASI KUANTITATIF PENGGUNAAN ANTIBIOTIK PASIEN RAWAT INAP PADA PERIODE SEBELUM DAN SELAMA PANDEMI COVID-19 DI RSUP. DR. HASAN SADIKIN BANDUNG

• Main Author: Widia Budhi, Monica
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/69344
• Institution: Institut Teknologi Bandung

Coronavirus disease 2019 or COVID-19 is an infectious disease caused by a new Corona virus called Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2. Since the beginning of the pandemic, specific therapy or treatment for COVID-19 is still not definitive, so many other treatment efforts are carried out, such as giving antibiotics. There is concern that the risk of antibiotic resistance will increase during the COVID-19 pandemic due to the widespread use of antibiotics in COVID-19 patients. Efforts to control the use of antibiotics can be carried out by quantitative evaluation of antibiotics before and during the COVID19 pandemic. This study aims to determine and compare the quantity of antibiotic use in the period before and during the COVID-19 pandemic and determine the pattern of antibiotic use before and during the COVID-19 pandemic at RSUP. Dr. Hasan Sadikin Bandung, which is one of the COVID-19 referral hospitals in West Java. Quantity of antibiotic use was expressed as defined daily doses per 100 days of hospitalization (DDD/100) and drug utilization 90% (DU90%). The research design was a descriptive crosssectional study with retrospective data collection in the period before the COVID-19 pandemic (March 2018-February 2020) and during the COVID-19 pandemic (March 2020-February 2022). The results showed that the use of antibiotics for two years before and the initial two years during COVID-19 in the inpatient ward (p = 0.306), the Intensive Care Unit/ICU ward (p = 0.317) and in the both wards (p = 0.16) had results that are not significantly different. The pattern of antibiotic use in inpatient and/or ICU ward showed that antibiotics that are always included in the 90% segment include ceftriaxone, levofloxacin, metronidazole, meropenem and ceftazidime. The selection of antibiotics in the 90% segment was dominated by broad-spectrum antibiotics, this showed that antibiotic therapy dominated by empiric therapy therefore this therapy must be immediately replaced by definitive therapy to minimize the risk of resistance to broad-spectrum antibiotics.