UJI AKTIVITAS NEFROPROTEKTIF KOMBINASI EKSTRAK ETANOL PEGAGAN (CENTELLA ASIATICA L.) URB.) DAN KUMIS KUCING (ORTHOSIPHON STAMINEUS BENTH.) TERHADAP MODEL HEWAN GAGAL GINJAL
Kidney diseases are abnormalities which affect kidney’s structure and function. There are 2 types of kidney disease: acute kidney injury (AKI) and chronic kidney disease (CKD). The purpose of this study was to determine the nephroprotective activity of the combination of gotu kola ethanolic extrac...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/69379 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Kidney diseases are abnormalities which affect kidney’s structure and function. There are 2 types of
kidney disease: acute kidney injury (AKI) and chronic kidney disease (CKD). The purpose of this study
was to determine the nephroprotective activity of the combination of gotu kola ethanolic extract and
java tea ethanolic extract in kidney disease animal model induced by gentamicin and piroxicam. Each
plant’s nephroprotective activity in kidney has been found. The study was done with 6 groups with 5
animals per group: negative control, positive control, P100 (gotu kola 100 mg/kgBW), KK200 (java tea
200 mg/kgBW), K100-200 (combination dose 100-200), and K50-100 (combination dose 50-100). All
groups except for the negative control group were induced with 100 mg/kgBW gentamicin
intraperitoneally and 3,6 mg/kgBW piroxicam orally for 7 days, continued by induction for another 21
days with 50 mg/kgBW gentamicin and 3,6 mg/kgBW piroxicam coinciding with the ethanolic extracts
given orally as therapy with doses according to each test group. Parameters for this study included
serum urea and creatinine, urinalysis, kidney index, and TNF-?. From the analysis results, it was
obtained that serum urea, serum creatinine, and TNF-?levels from all test groups were significantly
different than the positive control group (p < 0,05) and the lowest levels were from the K100-200
group. Kidney index from all test groups were not significantly different but still lower than the
positive control group and the lowest percentage was from the K100-200 group. Urinalysis results
from all test groups were nearing the negative control group. From those parameters, it was obtained
that the K100-200 group showed the best nephroprotective activity.
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