STABILITY IMPROVEMENT OF LIQUID CRYSTAL CREAM MORINGA OLEIFERA LEAF ETHANOLIC EXTRACT USING PROPYLENE GLYCOL AND FORMULA OPTIMIZATION WITH BEHNKEN BOX

• Main Author: Anjasari, Ufi
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/71001
• Institution: Institut Teknologi Bandung

One of the causes of dry skin is oxidative stress which triggers aging. Dry skin can be treated by the application of antioxidants in lamellar liquid crystal creams to prevent oxidative stress and replacing the skin's barrier function and providing a hydrating effect. Moringa oleifera leaves are a source of antioxidant that can be used to treat dry skin. This study aims to study the effect of propylene glycol on the stability and properties of liquid crystal cream of Moringa leaf extract. Formula optimization is done with the Behnken Box method. In this study, the liquid crystal cream formula of Moringa leaf extract was made using decyl glucoside (DG), cetostearyl alcohol (CA), and propylene glycol (PG). All formulas formed lamellar liquid crystals as evidenced by the presence of maltase cross from polarization microscopy observations. The addition of PG significantly affected the globule size, viscosity and spread ability. All lamellar liquid crystal cream formulas exhibit thixotropic flow properties. The in vitro occlusion factor test showed that a higher PG content resulted in a higher occlusion factor due to a decrease in globule size in formulas with high PG. DSC analysis showed that there was a peak shift in the formula containing PG. The formula without PG shows the peak evaporation of bulk water at 53.170C while the addition of PG causes no peak of evaporation of bulk water to be observed. The addition of PG in the formula can stabilize the emulsion in the freeze-thaw test. Stabilization in the presence of PG is by preventing the crystallization of fatty alcohol due to the interaction of PG and surfactants in forming lamellar liquid crystals that surround the oil droplets. Formula optimization carried out with the Behnken Box showed that the optimum formula for liquid crystal cream of Moringa leaf extract contained 3.48% DG, 7% CA, and 8.48% PG