FABRICATION OF SERICIN/POLYVINYLALCOHOL/MORINGA OLEIFERA HYDROGEL AS WOUND SCAFFOLD FOR DIABETIC FOOT ULCER

• Main Author: Sinthya Gita Ananda, Della
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/71110
• Institution: Institut Teknologi Bandung

Diabetes Mellitus (DM) can cause diabetic foot ulcers (DFU). Untreated DFU can become chronic and at risk of amputation. Hydrogel-based wound scaffolds are expected to cure diabetic foot ulcers at an early stage. Sericin, a protein derived from silkworm cocoons has potential as a wound scaffolding hydrogel, because it has anti-diabetic, anti-inflammatory and good adhesion properties to cells. One of the drawbacks of sericin is its low mechanical properties, therefore it needs to be combined with other polymers such as PVA. This research focuses on the manufacture of sericin/PVA hydrogels. Moringa oleifera leaf (MOL) herbal extract is added to the hydrogel to increase its antibacterial properties. Sericin was successfully isolated from silkworm cocoons by autoclave method. Hydrogels were synthesized with various concentrations and volume ratios of sericin and PVA, as well as MOL concentrations. The resulting hydrogel has an interconnected porous structure. Hydrogel with a concentration of 8% has better stability than 4%. A higher volume ratio of sericin to PVA results in a more porous hydrogel structure. The resulting hydrogels have a pore size range of 60-360 ?m. The hydrogel degradation results in PBS showed a fluctuating range of degradation due to the swelling and dissolving processes of the hydrogel components, in this case sericin and MOL. This research shows that sericin/PVA/MOL hydrogel has the potential to be developed as a wound scaffold for UKD.